Tisotumab vedotin
Tivdak (tisotumab vedotin) is an antibody drug conjugate pharmaceutical. Tisotumab vedotin was first approved as Tivdak on 2021-09-20. The pharmaceutical is active against tissue factor.
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Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 3 | 5 | 2 | — | — | 7 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 4 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | — | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 3 | — | — | — | 3 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 3 | — | — | — | 3 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | 3 | — | — | — | 3 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | 3 | — | — | — | 3 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | 3 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 2 | — | — | — | 2 |
| Fallopian tube neoplasms | D005185 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 1 | 1 |
| Agranulocytosis | D000380 | HP_0012234 | D70 | — | — | — | — | 1 | 1 |
| Toxemia | D014115 | — | — | — | — | — | — | 1 | 1 |
| Opportunistic infections | D009894 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tisotumab vedotin |
| INN | tisotumab vedotin |
| Description | Tisotumab vedotin, sold under the brand name Tivdak, is an antibody-drug conjugate used to treat cervical cancer. It is a combination of tisotumab, a monoclonal antibody against tissue factor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division. It is administered by infusion into a vein.
|
| Classification | Antibody |
| Drug class | synthetic analogs of the dolastatin series; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1418731-10-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297841 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB16732 |
| UNII ID | T41737F88A (ChemIDplus, GSRS) |
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Additional graphs summarizing 398 documents
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Black-box Warning
Black-box warning for: Tivdak
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438 adverse events reported
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